About
Amlodipine is a medicine used to treat high blood pressure (hypertension) and certain types of chest pain (angina). It belongs to a class of drugs called calcium channel blockers, which work by relaxing blood vessels so blood can flow more easily.
Amlodipine helps reduce blood pressure, lower the risk of heart attacks and strokes, and prevent chest pain caused by angina.
It is commonly prescribed for:
- High blood pressure (hypertension)
- Stable angina (chest pain)
- Prinzmetal’s (variant) angina
Amlodipine is usually available in the form of:
- Tablets (5 mg and 10 mg)
- Oral suspension or solution (in some formulations)
How and When to Use It
Take amlodipine exactly as prescribed by your doctor.
Dosage: The usual adult starting dose is 5 mg once daily, which may be increased to a maximum of 10 mg daily if needed.
It can be taken with or without food, at the same time each day.
Swallow the tablet with water. Do not chew or crush it.
Continue taking amlodipine even if you feel well — high blood pressure often has no symptoms. Do not stop suddenly without speaking to your doctor.
Contraindications
Amlodipine should not be used if you have:
- Allergy to amlodipine or any other calcium channel blocker
- Severe low blood pressure (hypotension)
- Shock (including cardiogenic shock)
- Heart failure due to recent heart attack (use with caution)
Side Effects
Like all medicines, amlodipine can cause side effects, although not everyone gets them.
Common side effects:
- Swelling of ankles or feet (oedema)
- Flushing or feeling warm
- Headache
- Dizziness or tiredness
- Palpitations (awareness of heartbeat)
Less common or serious side effects:
- Stomach pain, nausea, or indigestion
- Muscle cramps or weakness
- Allergic reactions (rash, itching, swelling)
- Severe low blood pressure or fainting (rare)
- Liver function changes (rare)
Contact your doctor if swelling, dizziness, or flushing become troublesome, or seek urgent medical help if you experience chest pain that worsens or sudden shortness of breath.
Pregnancy, Breastfeeding & Fertility
Amlodipine should only be used during pregnancy if advised by a doctor, as safety data is limited.
Small amounts may pass into breast milk, but it is not known to harm the baby. Your doctor may suggest alternative medicines if appropriate.
There is no evidence that amlodipine affects fertility in men or women.
Interactions With Other Medications
Amlodipine can interact with certain medications:
- Other blood pressure medicines — may increase the blood pressure–lowering effect
- Simvastatin — dose of simvastatin may need to be reduced
- Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin) — may increase amlodipine levels
- Grapefruit juice — may increase side effects
- Alcohol — can enhance dizziness and low blood pressure
Frequently Asked Questions
How long does it take for amlodipine to start working?
Amlodipine usually starts lowering blood pressure within 24–48 hours, but the full effect may take 1–2 weeks of regular use.
Can I drink alcohol while taking amlodipine?
Moderate alcohol is generally safe, but alcohol can increase blood pressure fluctuations or enhance dizziness. Avoid excessive drinking.
Why do my ankles swell when I take amlodipine?
Swelling of the ankles (peripheral edema) is a common side effect due to blood vessel dilation. Usually harmless but discuss with your doctor if severe.
Can I stop taking amlodipine if my blood pressure is normal?
No. Do not stop suddenly without medical advice. Stopping suddenly may cause a rebound increase in blood pressure.
Is it safe to take amlodipine with other blood pressure tablets?
Often yes. Amlodipine is commonly combined with other antihypertensives like ACE inhibitors or diuretics. Always follow your doctor’s prescription.
Can I drive while taking amlodipine?
Usually yes, but some people feel dizzy or lightheaded, especially when starting treatment. Ensure you feel safe before driving.
What should I do if I miss a dose?
Take it as soon as you remember, unless it’s almost time for the next dose. Do not double up on a dose.
Medical Disclaimer: This information is provided for educational purposes only and is not intended to replace professional medical advice, diagnosis, or treatment. Always consult a healthcare professional before starting, stopping, or changing any medication.
Last reviewed: June 2026
