About
Apixaban is a medicine used to prevent and treat blood clots. It belongs to a class of drugs called direct oral anticoagulants (DOACs), specifically a factor Xa inhibitor. It works by blocking part of the clotting process in your blood, reducing the risk of harmful clots forming.
Apixaban is commonly prescribed for:
- Preventing stroke and blood clots in people with atrial fibrillation (AF)
- Treating deep vein thrombosis (DVT)
- Treating pulmonary embolism (PE)
- Preventing recurrence of DVT or PE
- Preventing blood clots after hip or knee replacement surgery
Apixaban is available in:
- Tablets (2.5 mg and 5 mg)
How and When to Use It
Take apixaban exactly as prescribed by your doctor.
Dosage: Common doses are 2.5 mg or 5 mg taken twice daily. Your dose depends on your condition, kidney function, age, and body weight.
Take apixaban with or without food, at the same times each day.
Swallow the tablets whole with water. If you have trouble swallowing, they may be crushed and mixed with water or apple juice.
Do not stop taking apixaban suddenly — this may increase your risk of blood clots. Always check with your doctor first.
Contraindications
Do not take apixaban if you have:
- Allergy to apixaban or any of its ingredients
- Active bleeding or a condition that increases your bleeding risk
- Severe liver disease
- Artificial heart valves
Side Effects
Like all medicines, apixaban can cause side effects, although not everyone gets them.
Common side effects:
- Easy bruising
- Nosebleeds
- Bleeding gums
- Heavy or prolonged periods
- Minor bleeding after cuts
Serious side effects — seek medical attention immediately:
- Unexpected or severe bleeding (e.g., black stools, blood in urine)
- Severe headache or dizziness (possible internal bleeding)
- Swelling, pain, or shortness of breath
Because apixaban affects blood clotting, contact your doctor before any surgery, dental procedure, or new medication.
Pregnancy, Breastfeeding & Fertility
Apixaban is not usually recommended during pregnancy or breastfeeding, as its safety has not been fully established.
If you become pregnant while taking apixaban, inform your doctor immediately.
There is no evidence that apixaban affects fertility in men or women.
Interactions With Other Medications
Some medicines can increase your risk of bleeding or affect how apixaban works. Tell your doctor if you take:
- Other anticoagulants (e.g., warfarin, heparin)
- Antiplatelet drugs (e.g., aspirin, clopidogrel)
- NSAIDs (e.g., ibuprofen, naproxen)
- Certain antifungal or antibiotic medicines (e.g., ketoconazole, clarithromycin)
- Herbal supplements like St John’s wort
Frequently Asked Questions
What should I do if I miss a dose?
Take the missed dose as soon as you remember. If it’s almost time for your next dose, skip the missed one — do not double up.
Can I drink alcohol while taking apixaban?
Moderate alcohol is usually safe, but excessive drinking may increase the risk of bleeding. Avoid binge drinking.
Do I need regular blood tests?
No routine blood monitoring is needed for apixaban, unlike warfarin. However, your doctor may check kidney function or blood counts periodically.
Is apixaban better than warfarin?
Apixaban has some advantages, like fewer dietary restrictions and no routine blood monitoring, but whether it is “better” depends on your medical condition and doctor’s advice.
How long will I need to take apixaban?
The duration depends on your condition — it may be short-term for a clot or long-term for atrial fibrillation. Follow your doctor’s plan.
Can I take painkillers while on apixaban?
Some painkillers like NSAIDs can increase bleeding risk. Paracetamol is usually safer, but always check with your doctor or pharmacist.
What should I do before surgery or dental work?
Inform your doctor or dentist that you take apixaban. They may advise temporarily stopping it before certain procedures to reduce bleeding risk.
Medical Disclaimer: This information is provided for educational purposes only and is not intended to replace professional medical advice, diagnosis, or treatment. Always consult a healthcare professional before starting, stopping, or changing any medication.
Last reviewed: June 2026
